Ataluren treatment of patients with nonsense mutation dystrophinopathy
Identifieur interne : 003E49 ( Main/Exploration ); précédent : 003E48; suivant : 003E50Ataluren treatment of patients with nonsense mutation dystrophinopathy
Auteurs : Katharine Bushby [Royaume-Uni] ; Richard Finkel [États-Unis] ; Brenda Wong [États-Unis] ; Richard Barohn [États-Unis] ; Craig Campbell [Canada] ; Giacomo P. Comi [Italie] ; Anne M. Connolly [États-Unis] ; John W. Day [États-Unis] ; Kevin M. Flanigan [États-Unis] ; Nathalie Goemans [Belgique] ; Kristi J. Jones [Australie] ; Eugenio Mercuri [Italie] ; Ros Quinlivan [Royaume-Uni] ; James B. Renfroe [États-Unis] ; Barry Russman [États-Unis] ; Monique M. Ryan [Australie] ; Mar Tulinius [Suède] ; Thomas Voit [France] ; Steven A. Moore [États-Unis] ; H. Lee Sweeney [États-Unis] ; Richard T. Abresch [États-Unis] ; Kim L. Coleman [États-Unis] ; Michelle Eagle [Royaume-Uni] ; Julaine Florence [États-Unis] ; Eduard Gappmaier [États-Unis] ; Allan M. Glanzman [États-Unis] ; Erik Henricson [États-Unis] ; Jay Barth [États-Unis] ; Gary L. Elfring [États-Unis] ; Allen Reha [États-Unis] ; Robert J. Spiegel [États-Unis] ; Michael W. O'Donnell [États-Unis] ; Stuart W. Peltz [États-Unis] ; Craig M. Mcdonald [États-Unis]Source :
- Muscle & Nerve [ 0148-639X ] ; 2014-10.
Abstract
Introduction: Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was developed to enable ribosomal readthrough of premature stop codons in nonsense mutation (nm) genetic disorders. Methods: Randomized, double‐blind, placebo‐controlled study; males ≥5 years with nm‐dystrophinopathy received study drug orally 3 times daily, ataluren 10, 10, 20 mg/kg (N = 57); ataluren 20, 20, 40 mg/kg (N = 60); or placebo (N = 57) for 48 weeks. The primary endpoint was change in 6‐Minute Walk Distance (6MWD) at Week 48. Results: Ataluren was generally well tolerated. The primary endpoint favored ataluren 10, 10, 20 mg/kg versus placebo; the week 48 6MWD Δ = 31.3 meters, post hoc P = 0.056. Secondary endpoints (timed function tests) showed meaningful differences between ataluren 10, 10, 20 mg/kg, and placebo. Conclusions: As the first investigational new drug targeting the underlying cause of nm‐dystrophinopathy, ataluren offers promise as a treatment for this orphan genetic disorder with high unmet medical need. Muscle Nerve 50: 477–487, 2014
Url:
- https://api.istex.fr/document/00F023BC1A921FEE26F76EE7391CC836F6275129/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241581
DOI: 10.1002/mus.24332
Affiliations:
- Australie, Belgique, Canada, France, Italie, Royaume-Uni, Suède, États-Unis
- Angleterre, Floride, Grand Londres, Iowa, Kansas, Latium, Lombardie, Missouri (État), Nouvelle-Galles du Sud, Ohio, Oregon, Pennsylvanie, Victoria (État), Île-de-France
- Iowa City, Londres, Melbourne, Milan, Paris, Rome, Sydney
- Université de Melbourne, Université de Sydney, Université de l'Iowa
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Le document en format XML
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Comi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, I.R.C.C.S. Foundation Ca' Granda, Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Connolly, Anne M" sort="Connolly, Anne M" uniqKey="Connolly A" first="Anne M." last="Connolly">Anne M. Connolly</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine at St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Day, John W" sort="Day, John W" uniqKey="Day J" first="John W." last="Day">John W. Day</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Minnesota, Minnesota, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Flanigan, Kevin M" sort="Flanigan, Kevin M" uniqKey="Flanigan K" first="Kevin M." last="Flanigan">Kevin M. Flanigan</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nationwide Children's Hospital and the Ohio State University, Ohio, Columbus</wicri:regionArea><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Goemans, Nathalie" sort="Goemans, Nathalie" uniqKey="Goemans N" first="Nathalie" last="Goemans">Nathalie Goemans</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Kristi J" sort="Jones, Kristi J" uniqKey="Jones K" first="Kristi J." last="Jones">Kristi J. Jones</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Genetics, Sydney Children's Hospital Network, and Disciplines of Genetics and Paediatrics and Child Health, Faculty of Medicine University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Mercuri, Eugenio" sort="Mercuri, Eugenio" uniqKey="Mercuri E" first="Eugenio" last="Mercuri">Eugenio Mercuri</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Pediatric Neurology Unit, Polilcinico Gemelli, Università Cattolica Sacro Cuore, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Quinlivan, Ros" sort="Quinlivan, Ros" uniqKey="Quinlivan R" first="Ros" last="Quinlivan">Ros Quinlivan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Renfroe, James B" sort="Renfroe, James B" uniqKey="Renfroe J" first="James B." last="Renfroe">James B. Renfroe</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwest Florida Clinical Research Group, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Russman, Barry" sort="Russman, Barry" uniqKey="Russman B" first="Barry" last="Russman">Barry Russman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon Health & Science University and Shriners Hospital for Children, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Ryan, Monique M" sort="Ryan, Monique M" uniqKey="Ryan M" first="Monique M." last="Ryan">Monique M. Ryan</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Children's Hospital, Murdoch Childrens Research Institute and University of Melbourne, Victoria, Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tulinius, Mar" sort="Tulinius, Mar" uniqKey="Tulinius M" first="Mar" last="Tulinius">Mar Tulinius</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pediatrics, The University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Voit, Thomas" sort="Voit, Thomas" uniqKey="Voit T" first="Thomas" last="Voit">Thomas Voit</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Myologie, University Pierre et Marie Curie Paris 6, UM 76, INSERM U 974, CNRS UMR 7215, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moore, Steven A" sort="Moore, Steven A" uniqKey="Moore S" first="Steven A." last="Moore">Steven A. Moore</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Iowa, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Lee Sweeney, H" sort="Lee Sweeney, H" uniqKey="Lee Sweeney H" first="H." last="Lee Sweeney">H. Lee Sweeney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Abresch, Richard T" sort="Abresch, Richard T" uniqKey="Abresch R" first="Richard T." last="Abresch">Richard T. Abresch</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Physical Medicine & Rehabilitation, UC Davis Children's Hospital, Lawrence J. Ellison Ambulatory Care Center, 4860 Y St., Suite 1700, Sacramento, California, 95817</wicri:regionArea><wicri:noRegion>95817</wicri:noRegion></affiliation></author><author><name sortKey="Coleman, Kim L" sort="Coleman, Kim L" uniqKey="Coleman K" first="Kim L." last="Coleman">Kim L. Coleman</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>OrthoCare Innovations, Washington, Mountlake Terrace</wicri:regionArea><wicri:noRegion>Mountlake Terrace</wicri:noRegion></affiliation></author><author><name sortKey="Eagle, Michelle" sort="Eagle, Michelle" uniqKey="Eagle M" first="Michelle" last="Eagle">Michelle Eagle</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Florence, Julaine" sort="Florence, Julaine" uniqKey="Florence J" first="Julaine" last="Florence">Julaine Florence</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine at St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Gappmaier, Eduard" sort="Gappmaier, Eduard" uniqKey="Gappmaier E" first="Eduard" last="Gappmaier">Eduard Gappmaier</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah School of Medicine, Utah, Salt Lake City</wicri:regionArea><wicri:noRegion>Salt Lake City</wicri:noRegion></affiliation></author><author><name sortKey="Glanzman, Allan M" sort="Glanzman, Allan M" uniqKey="Glanzman A" first="Allan M." last="Glanzman">Allan M. Glanzman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children's Hospital of Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Henricson, Erik" sort="Henricson, Erik" uniqKey="Henricson E" first="Erik" last="Henricson">Erik Henricson</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Physical Medicine & Rehabilitation, UC Davis Children's Hospital, Lawrence J. Ellison Ambulatory Care Center, 4860 Y St., Suite 1700, Sacramento, California, 95817</wicri:regionArea><wicri:noRegion>95817</wicri:noRegion></affiliation></author><author><name sortKey="Barth, Jay" sort="Barth, Jay" uniqKey="Barth J" first="Jay" last="Barth">Jay Barth</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>PTC Therapeutics, New Jersey, South Plainfield</wicri:regionArea><wicri:noRegion>South Plainfield</wicri:noRegion></affiliation></author><author><name sortKey="Elfring, Gary L" sort="Elfring, Gary L" uniqKey="Elfring G" first="Gary L." last="Elfring">Gary L. Elfring</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>PTC Therapeutics, New Jersey, South Plainfield</wicri:regionArea><wicri:noRegion>South Plainfield</wicri:noRegion></affiliation></author><author><name sortKey="Reha, Allen" sort="Reha, Allen" uniqKey="Reha A" first="Allen" last="Reha">Allen Reha</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>PTC Therapeutics, New Jersey, South Plainfield</wicri:regionArea><wicri:noRegion>South Plainfield</wicri:noRegion></affiliation></author><author><name sortKey="Spiegel, Robert J" sort="Spiegel, Robert J" uniqKey="Spiegel R" first="Robert J." last="Spiegel">Robert J. Spiegel</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>PTC Therapeutics, New Jersey, South Plainfield</wicri:regionArea><wicri:noRegion>South Plainfield</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Michael W" sort="O Donnell, Michael W" uniqKey="O Donnell M" first="Michael W." last="O'Donnell">Michael W. O'Donnell</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>PTC Therapeutics, New Jersey, South Plainfield</wicri:regionArea><wicri:noRegion>South Plainfield</wicri:noRegion></affiliation></author><author><name sortKey="Peltz, Stuart W" sort="Peltz, Stuart W" uniqKey="Peltz S" first="Stuart W." last="Peltz">Stuart W. Peltz</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>PTC Therapeutics, New Jersey, South Plainfield</wicri:regionArea><wicri:noRegion>South Plainfield</wicri:noRegion></affiliation></author><author><name sortKey="Mcdonald, Craig M" sort="Mcdonald, Craig M" uniqKey="Mcdonald C" first="Craig M." last="Mcdonald">Craig M. Mcdonald</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Physical Medicine & Rehabilitation, UC Davis Children's Hospital, Lawrence J. Ellison Ambulatory Care Center, 4860 Y St., Suite 1700, Sacramento, California, 95817</wicri:regionArea><wicri:noRegion>95817</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Muscle & Nerve</title><title level="j" type="alt">MUSCLE AND NERVE</title><idno type="ISSN">0148-639X</idno><idno type="eISSN">1097-4598</idno><imprint><biblScope unit="vol">50</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="477">477</biblScope><biblScope unit="page" to="487">487</biblScope><biblScope unit="page-count">11</biblScope><date type="published" when="2014-10">2014-10</date></imprint><idno type="ISSN">0148-639X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0148-639X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Introduction: Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was developed to enable ribosomal readthrough of premature stop codons in nonsense mutation (nm) genetic disorders. Methods: Randomized, double‐blind, placebo‐controlled study; males ≥5 years with nm‐dystrophinopathy received study drug orally 3 times daily, ataluren 10, 10, 20 mg/kg (N = 57); ataluren 20, 20, 40 mg/kg (N = 60); or placebo (N = 57) for 48 weeks. The primary endpoint was change in 6‐Minute Walk Distance (6MWD) at Week 48. Results: Ataluren was generally well tolerated. The primary endpoint favored ataluren 10, 10, 20 mg/kg versus placebo; the week 48 6MWD Δ = 31.3 meters, post hoc P = 0.056. Secondary endpoints (timed function tests) showed meaningful differences between ataluren 10, 10, 20 mg/kg, and placebo. Conclusions: As the first investigational new drug targeting the underlying cause of nm‐dystrophinopathy, ataluren offers promise as a treatment for this orphan genetic disorder with high unmet medical need. Muscle Nerve 50: 477–487, 2014</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Floride</li><li>Grand Londres</li><li>Iowa</li><li>Kansas</li><li>Latium</li><li>Lombardie</li><li>Missouri (État)</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Oregon</li><li>Pennsylvanie</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Iowa City</li><li>Londres</li><li>Melbourne</li><li>Milan</li><li>Paris</li><li>Rome</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Sydney</li><li>Université de l'Iowa</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Bushby, Katharine" sort="Bushby, Katharine" uniqKey="Bushby K" first="Katharine" last="Bushby">Katharine Bushby</name></noRegion><name sortKey="Eagle, Michelle" sort="Eagle, Michelle" uniqKey="Eagle M" first="Michelle" last="Eagle">Michelle Eagle</name><name sortKey="Quinlivan, Ros" sort="Quinlivan, Ros" uniqKey="Quinlivan R" first="Ros" last="Quinlivan">Ros Quinlivan</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Finkel, Richard" sort="Finkel, Richard" uniqKey="Finkel R" first="Richard" last="Finkel">Richard Finkel</name></region><name sortKey="Abresch, Richard T" sort="Abresch, Richard T" uniqKey="Abresch R" first="Richard T." last="Abresch">Richard T. Abresch</name><name sortKey="Barohn, Richard" sort="Barohn, Richard" uniqKey="Barohn R" first="Richard" last="Barohn">Richard Barohn</name><name sortKey="Barth, Jay" sort="Barth, Jay" uniqKey="Barth J" first="Jay" last="Barth">Jay Barth</name><name sortKey="Coleman, Kim L" sort="Coleman, Kim L" uniqKey="Coleman K" first="Kim L." last="Coleman">Kim L. Coleman</name><name sortKey="Connolly, Anne M" sort="Connolly, Anne M" uniqKey="Connolly A" first="Anne M." last="Connolly">Anne M. Connolly</name><name sortKey="Day, John W" sort="Day, John W" uniqKey="Day J" first="John W." last="Day">John W. Day</name><name sortKey="Elfring, Gary L" sort="Elfring, Gary L" uniqKey="Elfring G" first="Gary L." last="Elfring">Gary L. Elfring</name><name sortKey="Flanigan, Kevin M" sort="Flanigan, Kevin M" uniqKey="Flanigan K" first="Kevin M." last="Flanigan">Kevin M. Flanigan</name><name sortKey="Florence, Julaine" sort="Florence, Julaine" uniqKey="Florence J" first="Julaine" last="Florence">Julaine Florence</name><name sortKey="Gappmaier, Eduard" sort="Gappmaier, Eduard" uniqKey="Gappmaier E" first="Eduard" last="Gappmaier">Eduard Gappmaier</name><name sortKey="Glanzman, Allan M" sort="Glanzman, Allan M" uniqKey="Glanzman A" first="Allan M." last="Glanzman">Allan M. Glanzman</name><name sortKey="Henricson, Erik" sort="Henricson, Erik" uniqKey="Henricson E" first="Erik" last="Henricson">Erik Henricson</name><name sortKey="Lee Sweeney, H" sort="Lee Sweeney, H" uniqKey="Lee Sweeney H" first="H." last="Lee Sweeney">H. Lee Sweeney</name><name sortKey="Mcdonald, Craig M" sort="Mcdonald, Craig M" uniqKey="Mcdonald C" first="Craig M." last="Mcdonald">Craig M. Mcdonald</name><name sortKey="Mcdonald, Craig M" sort="Mcdonald, Craig M" uniqKey="Mcdonald C" first="Craig M." last="Mcdonald">Craig M. Mcdonald</name><name sortKey="Moore, Steven A" sort="Moore, Steven A" uniqKey="Moore S" first="Steven A." last="Moore">Steven A. Moore</name><name sortKey="O Donnell, Michael W" sort="O Donnell, Michael W" uniqKey="O Donnell M" first="Michael W." last="O'Donnell">Michael W. O'Donnell</name><name sortKey="Peltz, Stuart W" sort="Peltz, Stuart W" uniqKey="Peltz S" first="Stuart W." last="Peltz">Stuart W. Peltz</name><name sortKey="Reha, Allen" sort="Reha, Allen" uniqKey="Reha A" first="Allen" last="Reha">Allen Reha</name><name sortKey="Renfroe, James B" sort="Renfroe, James B" uniqKey="Renfroe J" first="James B." last="Renfroe">James B. Renfroe</name><name sortKey="Russman, Barry" sort="Russman, Barry" uniqKey="Russman B" first="Barry" last="Russman">Barry Russman</name><name sortKey="Spiegel, Robert J" sort="Spiegel, Robert J" uniqKey="Spiegel R" first="Robert J." last="Spiegel">Robert J. Spiegel</name><name sortKey="Wong, Brenda" sort="Wong, Brenda" uniqKey="Wong B" first="Brenda" last="Wong">Brenda Wong</name></country><country name="Canada"><region name="Angleterre"><name sortKey="Campbell, Craig" sort="Campbell, Craig" uniqKey="Campbell C" first="Craig" last="Campbell">Craig Campbell</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="Comi, Giacomo P" sort="Comi, Giacomo P" uniqKey="Comi G" first="Giacomo P." last="Comi">Giacomo P. Comi</name></region><name sortKey="Mercuri, Eugenio" sort="Mercuri, Eugenio" uniqKey="Mercuri E" first="Eugenio" last="Mercuri">Eugenio Mercuri</name></country><country name="Belgique"><noRegion><name sortKey="Goemans, Nathalie" sort="Goemans, Nathalie" uniqKey="Goemans N" first="Nathalie" last="Goemans">Nathalie Goemans</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Jones, Kristi J" sort="Jones, Kristi J" uniqKey="Jones K" first="Kristi J." last="Jones">Kristi J. Jones</name></region><name sortKey="Ryan, Monique M" sort="Ryan, Monique M" uniqKey="Ryan M" first="Monique M." last="Ryan">Monique M. Ryan</name></country><country name="Suède"><noRegion><name sortKey="Tulinius, Mar" sort="Tulinius, Mar" uniqKey="Tulinius M" first="Mar" last="Tulinius">Mar Tulinius</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Voit, Thomas" sort="Voit, Thomas" uniqKey="Voit T" first="Thomas" last="Voit">Thomas Voit</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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